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KMID : 0939920230550010279
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대한암학회지
2023 Volume.55 No. 1 p.279 ~ p.290
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Epidemiologic and Clinical Outcomes of Pediatric Renal Tumors in Korea: A Retrospective Analysis of The Korean Pediatric Hematology and Oncology Group (KPHOG) Data
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Koh Kyung-Nam
Han Jung-Woo
Choi Hyung-Soo
Kang Hyoung-Jin
Lee Gee-Won
Yoo Keon-Hee
Sung Ki-Woong
Hong Kyung-Taek
Choi Jeong-Yun
Kang Sung-Han
Kim Hye-Ry
Im Ho-Joon
Han Sung-Min
Baek Hee-Jo
Kook Hoon
Park Kyung-Mi
Yang Eun-Jin
Kim Seong-Koo
Lee Jae-Wook
Cho Bin
Park Mee-Rim
Park Hyun-Jin
Lee Jun-Ah
Park Jun-Eun
Kim Ji-Yoon
Ma Young-Eun
Park Kyung-Duk
Park Sang-Kyu
Park Eun-Sil
Shim Ye-Jee
Yoo Eun-Sun
Yoo Jae-Won
Lim Yeon-Jung
Yoon Hoi-Soo
Lee Jae-Min
Jung Hye-Lim
Won Seung-Hyun
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Abstract
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Purpose : Renal tumors account for approximately 7% of all childhood cancers. These include Wilms tumor (WT), clear cell sarcoma of the kidney (CCSK), malignant rhabdoid tumor of the kidney (MRTK), renal cell carcinoma (RCC), congenital mesoblastic nephroma (CMN) and other rare tumors. We investigated the epidemiology of pediatric renal tumors in Korea.
Materials and Methods : From January 2001 to December 2015, data of pediatric patients (0?18 years) newly-diagnosed with renal tumors at 26 hospitals were retrospectively analyzed.
Results : Among 439 patients (male, 240), the most common tumor was WT (n=342, 77.9%), followed by RCC (n=36, 8.2%), CCSK (n=24, 5.5%), MRTK (n=16, 3.6%), CMN (n=12, 2.7%), and others (n=9, 2.1%). Median age at diagnosis was 27.1 months (range, 0 to 225.5 months) and median follow-up duration was 88.5 months (range, 0 to 211.6 months). Overall, 32 patients died, of whom 17, 11, 1, and three died of relapse, progressive disease, second malignant neoplasm, and treatment-related mortality. Five-year overall survival and event-free survival were 97.2% and 84.8% in WT, 90.6% and 82.1% in RCC, 81.1% and 63.6% in CCSK, 60.3% and 56.2% in MRTK, and 100% and 91.7% in CMN, respectively (p < 0.001).
Conclusion : The pediatric renal tumor types in Korea are similar to those previously reported in other countries. WT accounted for a large proportion and survival was excellent. Non-Wilms renal tumors included a variety of tumors and showed inferior outcome, especially MRTK. Further efforts are necessary to optimize the treatment and analyze the genetic characteristics of pediatric renal tumors in Korea.
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KEYWORD
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Kidney neoplasms, Child, Epidemiology
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